Basic information of IL7 :
| Official Symbol of Gene | IL7 |
| Species | Homo sapiens |
| Entrez Gene ID | 3574 |
| Official Full Name | interleukin 7 |
| Also known as | IL-7 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000104432 MIM:146660; AllianceGenome:HGNC:6023 |
| Map Location | 8q21.13 |
| Variation Type | SNP |
| refSNP ID | rs1520333 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR-RFLP |
| Disease | MS |
| Disease subtype | N/A |
| Population | Isfahan |
| Sample Size | 110 cases with MS / 110 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 25538924 |
| Year | 2014 |
| Title | Genetic association of rs1520333 G/A polymorphism in the IL7 gene with multiple sclerosis susceptibility in Isfahan population |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The frequency of the C allele in cases was more than that in the healthy control group.A notable association of the allele G and the GG genotype of rs1520333 SNP was detected with higher MS risk.For other genotypes of the rs1520333 polymorphism, results were not significantly associated with the risk for MS in the population under study. |
| Mechanism/Pathway | One of the new susceptibility genetic variants that have been introduced by a new GWAS is rs1520333 SNP in the IL-7 gene related to MS.The protein encoded by this gene is a cytokine that is secreted by stromal cells in the bone marrow and thymus.IL-7 cytokine plays an important role in immune system such as T-cell development, peripheral T-cell homeostasis, pre-B-cell growth factor and immune tolerance.MS usually has an autoimmune pathology in which TH1 and TH17 lymphocytes have a key contribution.In this pathology pathway, IL-7 cytokine directly elevated effector TH17 cells in human TH17 cells from subjects with MS;however, it is not necessary for TH17 differentiation. |
