Basic information of MMP9 :
| Official Symbol of Gene | MMP9 |
| Species | Homo sapiens |
| Entrez Gene ID | 4318 |
| Official Full Name | matrix metallopeptidase 9 |
| Also known as | GELB; CLG4B; MMP-9; MANDP2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000100985 MIM:120361; AllianceGenome:HGNC:7176 |
| Map Location | 20q13.12 |
| Variation Type | polymorphisms |
| refSNP ID | MMP-9 -1562 C/T |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS, SPMS |
| Population | Serbia |
| Sample Size | 187 MS patients / 282 healthy volunteers |
Literature information of multiple sclerosis :
| Pubmed ID | 17655938 |
| Year | 2007 |
| Title | Matrix metalloproteinase-9 -1562 C/T gene polymorphism in Serbian patients with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | In the patients group overall, genotype and allele frequency distributions were not significantly different between patients and controls. We found a significant decrease in T allele carrier frequency in female patients with MS compared to healthy female controls, which remained significant after correction for multiple testing. |
| Mechanism/Pathway | Matrix metalloproteinases (MMPs) are proteolytic enzymes involved in remodeling of the extracellular matrix.They are suggested to play a role in the influx of inflammatory cells into the CNS, disruption of the BBB, and have been shown to degrade myelin in vitro.Its production is instrumental in regulating the size-differentiated opening of the BBB during acute neuroinflammation. |
