Basic information of MMP9 :

Official Symbol of Gene	MMP9
Species	Homo sapiens
Entrez Gene ID	4318
Official Full Name	matrix metallopeptidase 9
Also known as	GELB; CLG4B; MMP-9; MANDP2
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000100985 MIM:120361; AllianceGenome:HGNC:7176
Map Location	20q13.12
Variation Type	polymorphisms
refSNP ID	MMP-9 -1562 C/T

Sample information of multiple sclerosis:

Detected Sample	peripheral blood leukocytes
Sample Detail	N/A
Detected Method	SSP-PCR
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	244 patients / 132 healthy subjects

Literature information of multiple sclerosis :

Pubmed ID	18835646
Year	2008
Title	Matrix metalloproteinase-9 and matrix metalloproteinase-2 gene polymorphisms in multiple sclerosis

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Positive
Result	A significant decrease of the -1562T allele carriers in MS patients compared to controls in -1562C/T MMP-9 gene polymorphism was found.Significant differences were also demonstrated between female patients and healthy females.
Mechanism/Pathway	The migration of autoreactive immune cells through the BBB into the CNS is crucial to the formation of inflammatory MS lesions.An important role in this process is played by matrix metalloproteinases (MMPs).In multiple sclerosis, they are assumed to act as effector molecules in the disruption of the BBB, invasion of inflammatory cells into the CNS parenchyma and degradation of myelin basic protein (MBP).