Basic information of CD226 :
| Official Symbol of Gene | CD226 |
| Species | Homo sapiens |
| Entrez Gene ID | 10666 |
| Official Full Name | CD226 molecule |
| Also known as | PTA1; DNAM1; DNAM-1; TLiSA1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000150637 MIM:605397; AllianceGenome:HGNC:16961 |
| Map Location | 18q22.2 |
| Variation Type | SNP |
| refSNP ID | rs763361 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Southern Han Chinese |
| Sample Size | 93 RRMS patients / 122 controls (CTLs) |
Literature information of multiple sclerosis :
| Pubmed ID | 22728856 |
| Year | 2021 |
| Title | CD226 Gly307Ser association with neuromyelitis optica in Southern Han Chinese |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | The frequency of T allele and TT genotype were also not increased in MS patients compare to the controls. |
| Mechanism/Pathway | CD226 belongs to the immunoglobulin supergene family of receptors and was widely expressed on the CD4+ and CD8+ T cells, natural killer cells, monocytes, b cells and platelets. CD226 could lead to various biological responses, including target cell lysis and immune cell activation.Rs763361/Gly307Ser in the immune response gene CD226 on chromosome 18q22 may increase the susceptibility of multiple autoimmune diseases, such as Type 1 diabetes (T1D), autoimmune thyroid disease (AITD) and rheumatoid arthritis (RA). |
