Basic information of DNMT3B :
| Official Symbol of Gene | DNMT3B |
| Species | Homo sapiens |
| Entrez Gene ID | 1789 |
| Official Full Name | DNA methyltransferase 3 beta |
| Also known as | ICF; ICF1; FSHD4; M.HsaIIIB |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000088305 MIM:602900; AllianceGenome:HGNC:2979 |
| Map Location | 20q11.21 |
| Variation Type | SNP |
| refSNP ID | rs1569686 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR-RFLP |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Iranian |
| Sample Size | 130 Iranian patients with MS / 130 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 31565203 |
| Year | 2019 |
| Title | DNMT3B-579G>T (rs1569686G>T) polymorphism and the risk of multiple sclerosis in a subset of Iranian population |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | There was no statistically significant association between DNMT3B-579G>T and susceptibility to MS. The alleles and genotypes of DNMT3B-579G>T did not have different risks of MS development under various models. |
| Mechanism/Pathway | Growing evidence about the relationship between methylation aberration or impaired DNMTs function and autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjogren's syndrome (SS), MS, psoriasis, and autoimmune thyroid diseases (AITD).DNMT3B gene has been mapped on chromosome 20q11.2 and encodes a DNMT enzyme contributing mainly in de novo methylation. Single nucleotide polymorphisms (SNPs) in this gene could affect the potential of DNA methylation, gene expression, and consequently, the development of various diseases. |
