Basic information of TNF :
| Official Symbol of Gene | TNF |
| Species | Homo sapiens |
| Entrez Gene ID | 7124 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000232810 MIM:191160; AllianceGenome:HGNC:11892 |
| Map Location | 6p21.33 |
| Variation Type | polymorphisms |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | polymorphism of TNF-α microsatellite |
| Disease | MS |
| Disease subtype | RRMS, SPMS, PPMS |
| Population | Iranian |
| Sample Size | 163 patients with MS / 82 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 25763268 |
| Year | 2014 |
| Title | Tumor necrosis factor-alpha polymorphism and susceptibility to multiple sclerosis in the Iranian population |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The frequencies of TNF-α*11 and TNF-α*10 alleles increased in patients with MS compared with controls, showing a significant difference among the studied population. |
| Mechanism/Pathway | N/A |
