Basic information of Il23a :
| Official Symbol of Gene | Il23a |
| Species | Mus musculus |
| Entrez Gene ID | 83430 |
| Official Full Name | Il23a |
| Also known as | p19; IL-23 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000025383 AllianceGenome:MGI:1932410 |
| Map Location | 10; 10 D3 |
| Variation Type | Deletion |
| refSNP ID | p19 -/- p19 +/- and p19 +/+ |
Sample information of multiple sclerosis:
| Detected Sample | tissues or cell pellets |
| Sample Detail | N/A |
| Detected Method | real-time PCR |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6 mice |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 12610626 |
| Year | 2003 |
| Title | Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result |
Mice lacking IL-23 ( p19 |
| Mechanism/Pathway | IL-23 may affect macrophage function directly.IL-23, unlike IL-12, acts more broadly as an end-stage effector cytokine through direct actions on macrophages. |
