Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | polymorphisms |
| refSNP ID | from DR1 to DR18 |
Sample information of multiple sclerosis:
| Detected Sample | mononuclear blood cells |
| Sample Detail | N/A |
| Detected Method | allele-specific PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 104 nuclear families, each of them comprising MS patients and their healthy parents |
Literature information of multiple sclerosis :
| Pubmed ID | 22649676 |
| Year | 2011 |
| Title | Family Analysis of Linkage and Association of HLA-DRB1, CTLA4, TGFB1, IL4, CCR5, RANTES, MMP9 and TIMP1 Gene Polymorphisms with Multiple Sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | We detected a significant linkage/association between MS and the HLA -DRB1 *15. |
| Mechanism/Pathway | A repeatedly confirmed fact is that particular alleles (depending on the population ethnicity) of the HLA -DRB1 gene class II are involved in the development of MS. This gene encodes the β-chain of the heterodimer, which presents the antigen to CD4+ T-lymphocytes. |
