Basic information of MMP9 :
| Official Symbol of Gene | MMP9 |
| Species | Homo sapiens |
| Entrez Gene ID | 4318 |
| Official Full Name | matrix metallopeptidase 9 |
| Also known as | GELB; CLG4B; MMP-9; MANDP2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000100985 MIM:120361; AllianceGenome:HGNC:7176 |
| Map Location | 20q13.12 |
| Variation Type | SNP |
| refSNP ID | rs3918242 |
Sample information of multiple sclerosis:
| Detected Sample | mononuclear blood cells |
| Sample Detail | N/A |
| Detected Method | PCR-RFLP |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 104 nuclear families, each of them comprising MS patients and their healthy parents |
Literature information of multiple sclerosis :
| Pubmed ID | 22649676 |
| Year | 2011 |
| Title | Family Analysis of Linkage and Association of HLA-DRB1, CTLA4, TGFB1, IL4, CCR5, RANTES, MMP9 and TIMP1 Gene Polymorphisms with Multiple Sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | We detected a significant linkage/association between MS and MMP9 *(–1562)С alleles. |
| Mechanism/Pathway | The matrix metalloproteinases (MMPs) play the key role in this barrier penetration.The MMPs are involved in various stages of MS pathogenesis: they participate in the local damaging of the hematoencephalic barrier and perivascular lymphocytes infiltration, in the damaging of myelin sheath and in the formation of the demyelination lesions and axonal death. One of the major metalloproteinases, MMP9, is expressed by perivascular mononuclear cells of white matter and, together with other MMPs, is associated with monocytes and astrocytes in the demyelination lesions. |
