Basic information of Ptgs2 :

Official Symbol of Gene	Ptgs2
Species	Mus musculus
Entrez Gene ID	19225
Official Full Name	prostaglandin-endoperoxide synthase 2
Also known as	COX2; Cox-2; PES-2; PHS-2; Pghs2; TIS10; PGHS-2; PHS II; gripghs
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000032487 AllianceGenome:MGI:97798
Map Location	1 G1; 1 63.84 cM
Variation Type	Deletion
refSNP ID	COX-2/

Sample information of multiple sclerosis:

Detected Sample	cerebral cortex
Sample Detail	N/A
Detected Method	Real-time PCR
Disease	EAE
Disease subtype	N/A
Population	male C57BL/6 mice
Sample Size	N/A

Literature information of multiple sclerosis :

Pubmed ID	21699540
Year	2012
Title	The cyclooxygenase-2 pathway via the PGE EP2 receptor contributes to oligodendrocytes apoptosis in cuprizone-induced demyelination

Results of multiple sclerosis :

Risk Type	Treatment risk
Main Result	Positive
Result	Similar results were observed in COX-2/ mice, which developed less demyelination than COX-2+/+ mice after 5 weeks of cuprizone.In the cortex, only COX-2+/+ mice developed a significant demyelination.
Mechanism/Pathway	Increased COX-2 expression in demyelinating lesions and increased PGs levels in the CSF of MS patients suggest that this pathway is involved in the disease, and studies in various animal models of demyelination support this concept.In the mouse model of Theiler’s encephalomyelitis virus (TMEV)-induced demyelination, COX-2 is expressed by mature oligodendrocytes undergoing apoptosis, suggesting that COX-2 plays a role in mediating oligodendrocytes apoptosis.