Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | SNP |
| refSNP ID | HLA-DRB1*15 allele(DRB1*01,DRB1*03,DRB1*04) |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | a low-resolution sequence-specific PCR amplification method |
| Disease | MS |
| Disease subtype | N/A |
| Population | Spanish |
| Sample Size | 380 patients/1088 healthy controls. |
Literature information of multiple sclerosis :
| Pubmed ID | 20629714 |
| Year | 2011 |
| Title | HLA-DRB1: genetic susceptibility and disability progression in a Spanish multiple sclerosis population |
Results of multiple sclerosis :
| Risk Type | Treatment risk |
| Main Result | Positive |
| Result | The HLA-DRB1*15 allele in patients with MS had a statistically significant higher frequency when compared with controls.In the univariate analysis, the DRB1*01 and DRB1*04 alleles were associated with a worse prognosis , whereas the DRB1*03 was correlated with a better outcome.In the multivariate analysis, the alleles*01 and *04 were demonstrated to be independent factors to have a worse prognosis. |
| Mechanism/Pathway | N/A |
