Basic information of IL10 :

Official Symbol of Gene	IL10
Species	Homo sapiens
Entrez Gene ID	3586
Official Full Name	interleukin 10
Also known as	CSIF; TGIF; GVHDS; IL-10; IL10A
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000136634 MIM:124092; AllianceGenome:HGNC:5962
Map Location	1q32.1
Variation Type	SNP
refSNP ID	IL-10 -1082 G/G and IL-10 -819 C/C

Sample information of multiple sclerosis:

Detected Sample	peripheral blood
Sample Detail	N/A
Detected Method	SSP-PCR
Disease	MS
Disease subtype	N/A
Population	Iranian
Sample Size	336 MS patients/454 healthy controls

Literature information of multiple sclerosis :

Pubmed ID	29067976
Year	2017
Title	Combination of interleukin-10 gene promoter polymorphisms with HLA-DRB1*15 allele is associated with multiple sclerosis

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Positive
Result	It was found that IL-10 1082 G/G genotype was associated with higher risk of MS in Iranian population, while G/A and A/A genotypes reduced the risk of the disease and 819 CC genotype was also associated with higher risk of developing MS.
Mechanism/Pathway	Interleukin 10 (IL-10) is an anti-inflammatory cytokine and the amount of IL-10 production has a direct association with the progression or recovery of MS . The three SNPs in the promoter region of IL-10 gene, 1082 G/A, 819 T/C and 592 A/C, have been shown to be in association with high or low production of this cytokine.