Basic information of APOE :

Official Symbol of Gene	APOE
Species	Homo sapiens
Entrez Gene ID	348
Official Full Name	apolipoprotein E
Also known as	AD2; LPG; APO-E; ApoE4; LDLCQ5
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000130203 MIM:107741; AllianceGenome:HGNC:613
Map Location	19q13.32
Variation Type	SNP
refSNP ID	SNP469,SNP457,SNP992,APOE,SNP952,SNP873,SNP888,SNP988

Sample information of multiple sclerosis:

Detected Sample	whole blood
Sample Detail	N/A
Detected Method	an oligonucleotide ligation assay
Disease	MS
Disease subtype	N/A
Population	white families
Sample Size	633 patients

Literature information of multiple sclerosis :

Pubmed ID	11836653
Year	2002
Title	Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Positive
Result	Both the global and haplotype-specific multilocus results indicated that the 21112 haplotype of markers APOE, snp952, snp873, snp888, and snp988 was associated with increased MS susceptibility.APOE-4 carriers are more likely to be affected with severe disease , whereas a higher proportion of APOE-2 carriers exhibit a mild disease course .No significant effect of APOE genotypes on rate of progression to disability was detected.
Mechanism/Pathway	One of several candidate genes in the 19q13 region is the APOE gene, which codes for a major lipid carrier protein (apoE) in the brain. The apoE protein has long been associated with regeneration of axons and myelin after lesions of central and peripheral nervous tissue, and its isoforms have been shown to have differential effects on neuronal growth.