Basic information of IFNG :
| Official Symbol of Gene | IFNG |
| Species | Homo sapiens |
| Entrez Gene ID | 3458 |
| Official Full Name | interferon gamma |
| Also known as | IFG; IFI; IMD69 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000111537 MIM:147570; AllianceGenome:HGNC:5438 |
| Map Location | 12q15 |
| Variation Type | SNP |
| refSNP ID | IFN-γ intron III (+2118 site A/G and +3586 site G/ACT). |
Sample information of multiple sclerosis:
| Detected Sample | venous blood |
| Sample Detail | N/A |
| Detected Method | PCR-RFL |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 58 patients/40 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 28218775 |
| Year | 2017 |
| Title | Polymorphism in the third intron of the interferonγ gene is associated with susceptibility to multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The frequency of the A allele at the IFN-γ +2118 site was increased in the MS group as compared with the control group.However, no significant difference was observed between the MS and control groups in genotype distribution and allele frequency at the IFN-γ +3586 site.Thus, polymorphisms at the +2118 A/G site in the IFN-γ intron III gene may be associated with susceptibility to multiple sclerosis. |
| Mechanism/Pathway | Interferon-gamma (IFN-γ), which is a pro-inflammatory cytokine secreted by Th1 cells, can regulate the activity of immune cells and induce general inflammation. Studies have shown that level of IFN-γ increases in the acute phase of MS. IFN-γ may therefore act as a direct inducer of demyelination in the central nervous system. |
