Basic information of IKZF3 :
| Official Symbol of Gene | IKZF3 |
| Species | Homo sapiens |
| Entrez Gene ID | 22806 |
| Official Full Name | IKAROS family zinc finger 3 |
| Also known as | AIO, AIOLOS, IMD84, ZNFN1A3 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000161405 MIM:606221; AllianceGenome:HGNC:13178 |
| Map Location | 17q12-q21.1 |
| Variation Type | SNP |
| refSNP ID | rs907091 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | qPCR,online tools SNAP |
| Disease | MS |
| Disease subtype | N/A |
| Population | Norwegian |
| Sample Size | 140 MS patients/46 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 27080863 |
| Year | 2016 |
| Title | Allelic imbalance of multiple sclerosis susceptibility genes IKZF3 and IQGAP1 in human peripheral blood |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The transcript of the haplotype containing the MS risk allele at rs907091 in IKZF3, showed consistently higher expression level in all MS samples.Consistent allelic imbalance is observed for rs907091 in IKZF3. The studied SNP in IKZF3 is located in a cis-regulatory element, or that these SNPs mark a functional cis-regulatory element that impacts the per-allele transcript abundance in whole blood, independent of disease status. |
| Mechanism/Pathway | N/A |
