Basic information of IL18 :
| Official Symbol of Gene | IL18 |
| Species | Homo sapiens |
| Entrez Gene ID | 3606 |
| Official Full Name | interleukin 18 |
| Also known as | IGIF; IL-18; IL-1g; IL1F4 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000150782 MIM:600953; AllianceGenome:HGNC:5986 |
| Map Location | 11q23.1 |
| Variation Type | SNP |
| refSNP ID | IL-18 -137C/G and -607C/A |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood and serum |
| Sample Detail | N/A |
| Detected Method | SS-PCR |
| Disease | MS |
| Disease subtype | Relapsing–Remitting (RRMS), Secondary Progressive (SP), Primary Progressive (PP) ,Relapsing Progressive (RP) |
| Population | N/A |
| Sample Size | 113 patients /135 ethnically-matched controls |
Literature information of multiple sclerosis :
| Pubmed ID | 27177146 |
| Year | 2016 |
| Title | The association of IL-18 gene promoter polymorphisms and the levels of serum IL-18 on the risk of multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | IL-18 -607AA genotype indicated 6 times higher risk in the development of MS . Smoking seems to be an important confounding factor in MS patients with carrying IL-18 -607 AA and CA+AA genotypes. However, no meaningful association was found with IL-18 -137C/G gene promoter polymorphism. |
| Mechanism/Pathway | IL18, is encoded by the IL18 gene, which induces severe inflammatory reactions. An important role of IL-18 has been shown in clinical implications such as elevated serum IL-18 levels in inflammatory as well as some autoimmune diseases including MS .A change at position -137 from G to C alters the H4TF-1 nuclear factor binding site, whereas a change from C to A at position -607 disrupts a potential cAMP-responsive element-binding protein binding site. |
