Basic information of IL32 :
| Official Symbol of Gene | IL32 |
| Species | Homo sapiens |
| Entrez Gene ID | 9235 |
| Official Full Name | interleukin 32 |
| Also known as | NK4; TAIF; TAIFa; TAIFb; TAIFc; TAIFd; IL-32beta; IL-32alpha; IL-32delta; IL-32gamma |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000008517 MIM:606001; AllianceGenome:HGNC:16830 |
| Map Location | 16p13.3 |
| Variation Type | SNP |
| refSNP ID | rs45499297 |
Sample information of multiple sclerosis:
| Detected Sample | antecubital vein |
| Sample Detail | N/A |
| Detected Method | PCR,RFLP analysis |
| Disease | MS |
| Disease subtype | RRMS,PPMS,SPMS |
| Population | Caucasian origin people |
| Sample Size | 132 MS /172 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 28716229 |
| Year | 2017 |
| Title | Association between interleukin-32 polymorphism and multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The presence of C allele might impact the risk of disease susceptibility up to 1.6 fold. Harboring CC genotype significantly increased IL-32 levels in both groups .ANOVA revealed a significance difference between age at disease onset and IL-32 T/C genotypes .Tukey’s Post Hoc test was shown a significant decreased in age at disease onset in CC genotype compared to CT genotype. C allele carriage patients were significantly younger than the T allele carrier patients .Comparison of MS symptoms in wild IL-32 genotype carriages with mutant C allele harboring subjects revealed no significant difference. |
| Mechanism/Pathway | N/A |
