Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | SNP |
| refSNP ID | HLA-DRB1*15+/- |
Sample information of multiple sclerosis:
| Detected Sample | whole blood |
| Sample Detail | N/A |
| Detected Method | qPCR |
| Disease | MS |
| Disease subtype | RR-MS,P-MS |
| Population | N/A |
| Sample Size | 64 MS patients/68 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 29587799 |
| Year | 2018 |
| Title | HLA alleles modulate EBV viral load in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result |
The relationship between HLA alleles and viral parameters was exclusively seen in MS patient.MS patients carrying the HLA-DRB1*15 allele (HLA-DRB1*15+) (N = 42/117) had higher EBV viral load than those not carrying this allele (HLA-DRB1*15 |
| Mechanism/Pathway | HLA-class I molecules present antigens to T lymphocytes and initiate immune response against viruses. |
