Basic information of NOS2 :
| Official Symbol of Gene | NOS2 |
| Species | Homo sapiens |
| Entrez Gene ID | 4843 |
| Official Full Name | nitric oxide synthase 2 |
| Also known as | NOS; INOS; NOS2A; HEP-NOS |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000007171 MIM:163730; AllianceGenome:HGNC:7873 |
| Map Location | 17q11.2 |
| Variation Type | SNP |
| refSNP ID | Exon 10 C/T |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR,microsatellite markers |
| Disease | MS |
| Disease subtype | N/A |
| Population | African American |
| Sample Size | 442 MS patients/293 control |
Literature information of multiple sclerosis :
| Pubmed ID | 15174013 |
| Year | 2004 |
| Title | Linkage and association with the NOS2A locus on chromosome 17q11 in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | A significant increase in frequency of the less common NOS2A exon10 SNP-T allele was observed. |
| Mechanism/Pathway | The NOS2A locus encodes one of the three isoforms of nitric oxide (NO) synthase, inducible NOS2 oriNOS, and is a very plausible MS candidate gene based on the well-known biological functions attributed to this enzyme. |
