Basic information of CTLA4 :
| Official Symbol of Gene | CTLA4 |
| Species | Homo sapiens |
| Entrez Gene ID | 1493 |
| Official Full Name | cytotoxic T-lymphocyte associated protein 4 |
| Also known as | CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000163599 MIM:123890; AllianceGenome:HGNC:2505 |
| Map Location | 2q33.2 |
| Variation Type | SNP |
| refSNP ID | CTLA-4-318, CTLA-4+49 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS,PPMS,SPMS |
| Population | Dutch |
| Sample Size | 514 MS patients/181 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 12864988 |
| Year | 2003 |
| Title | CTLA-4 and CD28 gene polymorphisms in susceptibility, clinical course and progression of multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | We found no association between carriership of any of the alleles either with susceptibility to MS or with clinical features and the polymorphisms under investigation do not affect the risk of developing MS and have no influence on the course of disease. |
| Mechanism/Pathway | CTLA-4 may actually down regulate T cell function . |
