Basic information of Tyk2 :
| Official Symbol of Gene | Tyk2 |
| Species | Mus musculus |
| Entrez Gene ID | 54721 |
| Official Full Name | tyrosine kinase 2 |
| Also known as | JTK1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000032175 AllianceGenome:MGI:1929470 |
| Map Location | 9; 9 A3 |
| Variation Type | SNP |
| refSNP ID | Tyk2rs2538-A,Tyk2rs2538-G |
Sample information of multiple sclerosis:
| Detected Sample | spleens and draining lymph nodes |
| Sample Detail | N/A |
| Detected Method | Bioplex multiplex cytokine assay,ELISA |
| Disease | EAE |
| Disease subtype | N/A |
| Population | B10.D1-H2q/SgJ (B10.D1) (Strain #002024),B10.Q/Ai (Line #4059) |
| Sample Size | B10.Q/Ai mice (n = 36) /B10.D1(n = 46)/(B10.Q/Ai × B10.D1)(n = 31) /(B10.D1 × B10.Q/Ai)(n = 18) |
Literature information of multiple sclerosis :
| Pubmed ID | 19494301 |
| Year | 2009 |
| Title | A single nucleotide polymorphism in Tyk2 controls susceptibility to experimental allergic encephalomyelitis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | B10.D1 mice were resistant to EAE whereas B10.Q/Ai mice were susceptible .The susceptible B10.Q/Ai mice had marked EAE pathology in the spinal cord while B10.D1 had no EAE pathology. |
| Mechanism/Pathway | N/A |
