Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | SNP |
| refSNP ID | rs3135388 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | iPlex SNP assay design system |
| Disease | MS |
| Disease subtype | RRMS,PPMS |
| Population | Austria |
| Sample Size | 883 patients/972 control individuals |
Literature information of multiple sclerosis :
| Pubmed ID | 22411505 |
| Year | 2012 |
| Title | Replication study of multiple sclerosis (MS) susceptibility alleles and correlation of DNA-variants with disease features in a cohort of Austrian MS patients |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | We observed a trend for association of rs3135388 (HLA-DRB1*1501)with a younger age at MS onset and have remained significant when being over conservative and adjusting for multiple testing. |
| Mechanism/Pathway | N/A |
