Basic information of Ciita :
| Official Symbol of Gene | Ciita |
| Species | Rattus norvegicus |
| Entrez Gene ID | 85483 |
| Official Full Name | class II, major histocompatibility complex, transactivator |
| Also known as | C2ta; Mhc2ta |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSRNOG00000002659 AllianceGenome:RGD:619813 |
| Map Location | 10q11 |
| Variation Type | allele |
| refSNP ID | Vra4 |
Sample information of multiple sclerosis:
| Detected Sample | tail tips or ear clippings |
| Sample Detail | N/A |
| Detected Method | RT-PCR |
| Disease | EAE |
| Disease subtype | N/A |
| Population | DA,PVGav1 |
| Sample Size | DA (n=5)/PVGav1-Vra4 (n=5) |
Literature information of multiple sclerosis :
| Pubmed ID | 18292553 |
| Year | 2008 |
| Title | Vra4 congenic rats with allelic differences in the class II transactivator gene display altered susceptibility to experimental autoimmune encephalomyelitis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | PVGav1-Vra4 rats displayed a lower disease incidence and milder disease course compared with DA, whereas both PVGav1 and PVGav1. DA-Vra4 rats were completely protected. |
| Mechanism/Pathway | Naturally occurring allelic differences in Mhc2ta have profound effects on the quantity of MHC II expression in the CNS and on immune cells and that this genetic variability also modulates susceptibility to autoimmune neuroinflammation. |
