Basic information of NFKBIA :
| Official Symbol of Gene | NFKBIA |
| Species | Homo sapiens |
| Entrez Gene ID | 4792 |
| Official Full Name | NFKB inhibitor alpha |
| Also known as | IKBA; MAD-3; NFKBI; EDAID2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000100906 MIM:164008; AllianceGenome:HGNC:7797 |
| Map Location | 14q13.2 |
| Variation Type | SNP |
| refSNP ID | rs3138053 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS,PPMS,SPMS |
| Population | Iranian |
| Sample Size | 150 patients / 150 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 24368589 |
| Year | 2014 |
| Title | Inhibitor IκBα promoter functional polymorphisms in patients with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The genotype frequencies of IκBα-881A/G and allele frequencies of IκBα-881G were significantly higher in patients with MS with respect to as compared to the controls. |
| Mechanism/Pathway | NF-kB plays a substantial role in inflammatory diseases and in the development of autoimmunity such as multiple sclerosis .The anti-apoptogenic effect of NF-jB is well documented. Inhibitor of kappa B (IkB) is an inhibitor of NF-kB, which binds withNF-kB in the cytoplasm and controls the transcriptional activity of NF-kB. |
