Basic information of IL6 :

Official Symbol of Gene	IL6
Species	Homo sapiens
Entrez Gene ID	3569
Official Full Name	interleukin 6
Also known as	CDF; HGF; HSF; BSF2; IL-6; BSF-2; IFNB2; IFN-beta-2
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000136244 MIM:147620; AllianceGenome:HGNC:6018
Map Location	7p15.3
Variation Type	allele
refSNP ID	A1,A2,A3,A4,A5,A6,A7,A8d,A9

Sample information of multiple sclerosis:

Detected Sample	N/A
Sample Detail	N/A
Detected Method	N/A
Disease	MS
Disease subtype	N/A
Population	Sardinian
Sample Size	192 simplex MS families/ 135 healthy controls

Literature information of multiple sclerosis :

Pubmed ID	11196678
Year	2000
Title	High-resolution analysis of IL-6 minisatellite polymorphism in Sardinian multiple sclerosis: effect on course and onset of disease

Results of multiple sclerosis :

Risk Type	Phenotypic risk
Main Result	Positive
Result	Analysis of clinically different groups showed that the A5 allele was associated with a benign but not with a malignant course of disease.In particular, the frequency of the A5/A5 genotype was significantly higher in patients with benign MS.In addition, carriage of any of the larger alleles (A6->A9) was associated with accelerated onset of disease.
Mechanism/Pathway	Part of this beneficial effect has been attributed to the ability of this cytokine to induce protease inhibitors.