Basic information of TRBV20OR9-2 :
| Official Symbol of Gene | TRBV20OR9-2 |
| Species | Homo sapiens |
| Entrez Gene ID | 6962 |
| Official Full Name | T cell receptor beta variable 20/OR9-2 (non-functional) |
| Also known as | TCR; TRB; CDR3; TCRB; TCRBV2O; TCRBV20S2; TCRBV2S2O |
| Gene Type | pseudo |
| dbXrefs | Ensembl:ENSG00000205274 IMGT/GENE-DB:TRBV20/OR9-2; AllianceGenome:HGNC:12197 |
| Map Location | 9p13.3 |
| Variation Type | allele |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | venous blood |
| Sample Detail | N/A |
| Detected Method | PCR,Southern blot hybridizations |
| Disease | MS |
| Disease subtype | N/A |
| Population | Caucasian |
| Sample Size | 83 MS patients/197 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 8101191 |
| Year | 1993 |
| Title | Susceptibility for multiple sclerosis is determined, in part, by inheritance of a 175-kb region of the TcR V beta chain locus and HLA class II genes |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Genotypes in the normal populations were compared to those in the MS population .The genotype frequencies were not significantly different between the MS and control populations at positions 1-4 and 6 (Vβ7/BamHI and Vβ15/MSP 1 markers, Vβ1/TaqI and Vβ8/MSP 1 markers ,Vβ8/BamHI.) However, at marker 5 defined by the Vβ11/BarnHI RFLP, the genotype frequencies were significantly different between the MS and control populations.These subhaplotype frequency distributions were not significantly different among the control populations.The subhaplotype frequency distributions spanning the markers * 4 and * 5 were found to be significantly different between the MS and control population . |
| Mechanism/Pathway | N/A |
