Basic information of ERG :
| Official Symbol of Gene | ERG |
| Species | Homo sapiens |
| Entrez Gene ID | 2078 |
| Official Full Name | ETS transcription factor ERG |
| Also known as | p55; erg-3 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000157554 MIM:165080; AllianceGenome:HGNC:3446 |
| Map Location | 21q22.2 |
| Variation Type | polymorphism |
| refSNP ID | PvuII |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | RFLP |
| Disease | MS |
| Disease subtype | RRMS, SPMS |
| Population | Japanese |
| Sample Size | 116 MS patients / 101 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 12098513 |
| Year | 2002 |
| Title | Estrogen receptor gene polymorphism and multiple sclerosis in Japanese patients: interaction with HLA-DRB1*1501 and disease modulation |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The rate of PP and Pp genotype and the [P] allele frequency were significantly higher in MS patients than in controls, both in the total study population and in female subjects. |
| Mechanism/Pathway | Biological actions of estrogen are mediated through intranuclear estrogen receptors, and estrogen receptors (ER) are expressed in cells involved in the immune response. |
