Basic information of CD24 :
| Official Symbol of Gene | CD24 |
| Species | Homo sapiens |
| Entrez Gene ID | 100133941 |
| Official Full Name | CD24 molecule |
| Also known as | CD24A |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000272398 MIM:600074; AllianceGenome:HGNC:1645 |
| Map Location | 6q21 |
| Variation Type | SNP |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR-RFLP |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Iranian |
| Sample Size | 120 MS / 120 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 21815873 |
| Year | 2011 |
| Title | Investigation of CD24 and its expression in Iranian relapsing-remitting multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | A comparison of genotype frequencies between MS patients and controls indicates that the CD24v/v genotype was significantly more frequent in MS patients than in controls.The results showed a significant difference in the MSSS of the three different genotypes.These data suggest that the CD24v/v genotype may influence both disease susceptibility and severity in Iranian MS patients. |
| Mechanism/Pathway | CD24 is one of the non-HLA genes suggested to contribute to the pathogenesis of MS. It is a glycosylphosphatidylinositol (GPI)-linked cell surface glycoprotein expressed in a broad range of hematopoietic system cells, including T cells, B cells, macrophages, and neutrophils.It ′is also known that CD24 is abundantly expressed in CNS cells such as astrocytes and microglia.CD24 contributes to the pathogenesis of MS through several mechanisms, including expansion of autoreactive T cells in the target organ and regulation of homeostatic proliferation. |
