Basic information of STK11 :
| Official Symbol of Gene | STK11 |
| Species | Homo sapiens |
| Entrez Gene ID | 6794 |
| Official Full Name | serine/threonine kinase 11 |
| Also known as | PJS; LKB1; hLKB1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000118046 MIM:602216; AllianceGenome:HGNC:11389 |
| Map Location | 19p13.3 |
| Variation Type | SNP |
| refSNP ID | rs9282860 |
Sample information of multiple sclerosis:
| Detected Sample | whole blood |
| Sample Detail | N/A |
| Detected Method | TaqMan quantitative PCR assay |
| Disease | MS |
| Disease subtype | RRMS, PPMS |
| Population | European |
| Sample Size | 754 MS patients / 661 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 25694554 |
| Year | 2015 |
| Title | A single-nucleotide polymorphism in serine-threonine kinase 11, the gene encoding liver kinase B1, is a risk factor for multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The STK11-SNP has increased frequency in all female patients versus controls. |
| Mechanism/Pathway | STK11 (serine-threonine-kinase 11) codes for liver kinase B1 (LKB1), a tumor suppressor gene. LKB1 functions upstream of at least 14 other protein kinases and, in that sense, is considered a master kinase with roles in numerous cellular functions. The wide array of functions regulated by LKB1 that have been implicated in the pathogenesis of MS suggest that alterations in LKB1 expression or activity may be a contributing factor to MS disease. |
