Basic information of IL27 :

Official Symbol of Gene	IL27
Species	Homo sapiens
Entrez Gene ID	246778
Official Full Name	interleukin 27
Also known as	p28; IL30; IL-27; IL27A; IL-27A; IL27p28
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000197272 MIM:608273; AllianceGenome:HGNC:19157
Map Location	16p12.1-p11.2
Variation Type	polymorphism
refSNP ID	N/A

Sample information of multiple sclerosis:

Detected Sample	peripheral blood
Sample Detail	N/A
Detected Method	PCR-restriction fragment length polymorphism analysis
Disease	MS
Disease subtype	N/A
Population	Roman
Sample Size	51 patients diagnosed with MS / 31 healthy controls

Literature information of multiple sclerosis :

Pubmed ID	34410977
Year	2021
Title	IL27 T4730C Polymorphism and Serology in Multiple Sclerosis: A Pilot Study

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Positive
Result	Carriers of the T4730С polymorphism were found to have a 6-fold increased risk for MS. Univariate logistic regression analysis showed an increased frequency of the TC4730 heterozygous genotype and also of the C4730 allele in patients compared to controls, with a 6.02-fold increased risk and a 4.31-fold increased risk of developing MS.
Mechanism/Pathway	IL27 is a novel member of the IL12 family, known for both its pro- and anti-inflammatory functions, with distinct roles in shaping the activity of T-cells. IL27 regulates the immune response through its heterodimeric IL27Ra/GP130 receptor, activating multiple signaling cascades.In the brain, IL27 produced by astrocytes and microglial cells is recognized for its neuroprotective effects, enhancing the production of nerve growth factor and neurotrophic factor, promoting remyelination.