Basic information of HLA-DPA1 :
| Official Symbol of Gene | HLA-DPA1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3113 |
| Official Full Name | major histocompatibility complex, class II, DP alpha 1 |
| Also known as | DPA1; PLT1; HLADP; HLASB; DP(W3); DP(W4); HLA-DPA; HLA-DP1A; HLA-DPB1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000231389 MIM:142880; AllianceGenome:HGNC:4938 |
| Map Location | 6p21.32 |
| Variation Type | polymorphism |
| refSNP ID | HLA-DPw4 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | Primed Lymphocyte Typing, RFLP |
| Disease | MS |
| Disease subtype | N/A |
| Population | Swedish MS patients, Danish controls |
| Sample Size | 45 MS patients / 166 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 3400089 |
| Year | 1988 |
| Title | HLA-DP antigens are involved in the susceptibility to multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | HLA-DPw4 was found in 93.3% of MS patients compared to 72.3% of controls.DPw4 seems to confer susceptibility to MS independently . |
| Mechanism/Pathway | The genetic susceptibility to multiple sclerosis (MS) is at least partly controlled by one or more genes in the class â…¡ region of the HLA system. |
