Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | polymorphism |
| refSNP ID | HLA-DR2 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | Primed Lymphocyte Typing, RFLP |
| Disease | MS |
| Disease subtype | N/A |
| Population | Swedish MS patients, Danish controls |
| Sample Size | 45 MS patients / 166 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 3400089 |
| Year | 1988 |
| Title | HLA-DP antigens are involved in the susceptibility to multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | DR2 was found in 75.5% of MS patients compared to 33.7% of controls.DR2 seems to confer susceptibility to MS independently . |
| Mechanism/Pathway | The genetic susceptibility to multiple sclerosis (MS) is at least partly controlled by one or more genes in the class â…¡ region of the HLA system. |
