Basic information of PVR :
| Official Symbol of Gene | PVR |
| Species | Homo sapiens |
| Entrez Gene ID | 5817 |
| Official Full Name | PVR cell adhesion molecule |
| Also known as | PVS; HVED; CD155; NECL5; TAGE4; Necl-5 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000073008 MIM:173850; AllianceGenome:HGNC:9705 |
| Map Location | 19q13.31 |
| Variation Type | polymorphism |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR-RFLP |
| Disease | MS |
| Disease subtype | RRMS, PPMS, SPMS |
| Population | N/A |
| Sample Size | 267 patients / 227 healthy donors |
Literature information of multiple sclerosis :
| Pubmed ID | 15465608 |
| Year | 2004 |
| Title | The role of the polio virus receptor and the herpesvirus entry mediator B genes for the development of MS |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | We did not find a significant difference in the frequency of the four polymorphisms in the PVR gene between MS patients and controls. |
| Mechanism/Pathway | PVR mediates entry of neurotropic viruses to the brain.Functional PVR, called the bona fide receptor, is essential for entry of the polio virus in neurons. In the CNS, both receptors are structural CNS proteins and important for cellular interactions. |
