Basic information of IL7 :
| Official Symbol of Gene | IL7 |
| Species | Homo sapiens |
| Entrez Gene ID | 3574 |
| Official Full Name | interleukin 7 |
| Also known as | IL-7 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000104432 MIM:146660; AllianceGenome:HGNC:6023 |
| Map Location | 8q21.13 |
| Variation Type | SNP |
| refSNP ID | rs1520333 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Chinese Han |
| Sample Size | 159 MS / 468 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 26608987 |
| Year | 2015 |
| Title | Variants of Interleukin-7/Interleukin-7 Receptor Alpha are Associated with Both Neuromyelitis Optica and Multiple Sclerosis Among Chinese Han Population in Southeastern China |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The frequency of the A/A genotype of rs1520333 in IL-7 gene of MS patients was observed dramatically lower than healthy controls, which reached the statistical difference. However, the allelic comparisons did not show the statistical significance. |
| Mechanism/Pathway | Interleukin-7 (IL-7) was proved to be important in the pathogenesis of both diseases because of the roles it played in the differentiations of autoimmune lymphocytes. |
