Basic information of TNFRSF1A :
| Official Symbol of Gene | TNFRSF1A |
| Species | Homo sapiens |
| Entrez Gene ID | 7132 |
| Official Full Name | TNF receptor superfamily member 1A |
| Also known as | FPF; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000067182 MIM:191190; AllianceGenome:HGNC:11916 |
| Map Location | 12p13.31 |
| Variation Type | SNP |
| refSNP ID | rs1800693 |
Sample information of multiple sclerosis:
| Detected Sample | blood and saliva samples |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS, SPMS |
| Population | Kuwaiti |
| Sample Size | 170 MS patients / 311 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 32355262 |
| Year | 2020 |
| Title | Replication analysis of variants associated with multiple sclerosis risk |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | TNFRSF1A rs1800693C allele did not sustain significant association with MS risk following adjustment for multiple testing. |
| Mechanism/Pathway | TNFRSF1A is a membrane-bound and soluble receptor for tumor necrosis factor-alpha (TNFα) that plays a role in cellular survival, apoptosis and inflammation in the immune and nervous systems. |
