Basic information of B2m :

Official Symbol of Gene	B2m
Species	Homo sapiens
Entrez Gene ID	12010
Official Full Name	beta-2 microglobulin
Also known as	Ly-m11; beta2m; beta2-m
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000060802 AllianceGenome:MGI:88127
Map Location	2 E5; 2 60.55 cM
Variation Type	Deletion
refSNP ID	class I-deficient (β2m/)

Sample information of multiple sclerosis:

Detected Sample	N/A
Sample Detail	N/A
Detected Method	N/A
Disease	persistent demyelination
Disease subtype	causing by Theiler’s murine encephalomyelitis virus (TMEV)
Population	SJL/J mice, C57BL/6 mice
Sample Size	24 SJL/J mice / 20 C57BL/6×129/J (H-22,β2m+/+)mice / 15 C57BL/6F×129/J (H–2b)β2m/ mice / 14 C57BL/6×129/J (H–2b) Ab°(class II-deficient mice)

Literature information of multiple sclerosis :

Pubmed ID	9461192
Year	1998
Title	Absence of neurological deficits following extensive demyelination in a class I-deficient murine model of multiple sclerosis

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Positive
Result	There was extensive demyelination in the spinal cords of chronically infected class I-deficient and class II-deficient mice of the identical resistant H–2b genotype.
Mechanism/Pathway	Alterations in the cytokines secreted and the distributions of T cells present in the lesions of class I-deficient mice may contribute to the absence of neurologic deficit following demyelination.