Basic information of MBP :
| Official Symbol of Gene | MBP |
| Species | Homo sapiens |
| Entrez Gene ID | 4155 |
| Official Full Name | myelin basic protein |
| Also known as | N/A |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000197971 MIM:159430; AllianceGenome:HGNC:6925 |
| Map Location | 18q23 |
| Variation Type | DNA length polymorphism |
| refSNP ID | RraI, EcoR |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | RFLP |
| Disease | MS |
| Disease subtype | RRMS, chronic progressive-MS |
| Population | Caucasians of northern European extraction |
| Sample Size | 65 patients with MS / 63 control subjects |
Literature information of multiple sclerosis :
| Pubmed ID | 1691612 |
| Year | 1990 |
| Title | DNA length polymorphism 5' to the myelin basic protein gene is associated with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | These data suggest that patients with MS differ from population-matched control subjects with respect to DNA polymorphism linked to the myelin basic protein gene but no pathogenic relationship between this polymorphism and MS can be presupposed. |
| Mechanism/Pathway | Parallels between EAE and MS suggest that MBP polymorphism could result in enhanced MBP autoantigenicity, thereby contributing to autoimmune CNS demyelination . |
