Basic information of TNFRSF14 :
| Official Symbol of Gene | TNFRSF14 |
| Species | Homo sapiens |
| Entrez Gene ID | 8764 |
| Official Full Name | TNF receptor superfamily member 14 |
| Also known as | TR2; ATAR; HVEA; HVEM; CD270; LIGHTR |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000157873 MIM:602746; AllianceGenome:HGNC:11912 |
| Map Location | 1p36.32 |
| Variation Type | SNP |
| refSNP ID | rs6684865(*)A |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | N/A |
| Disease | MS |
| Disease subtype | N/A |
| Population | Spanish |
| Sample Size | 1370 MS patients / 1715 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 20962851 |
| Year | 2011 |
| Title | Members 6B and 14 of the TNF receptor superfamily in multiple sclerosis predisposition |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The frequencies of the common allele and common genotype of rs6684865 were significantly higher in MS patients than in healthy controls. |
| Mechanism/Pathway | T-cell receptor engagement without costimulation leads to suboptimal T-cell activation and T-cell anergy.Two main superfamilies of co-signalling molecules based on their structure modulate the T-cell response: the immunoglobulin superfamily and the tumour necrosis factor receptor superfamily (TNFRSF).One of these TNFRSF members is HVEM (herpes virus entry mediator or TNFRSF14), a molecular switch that regulates the host immune response depending on which ligand it binds. |
