Basic information of MOG :
| Official Symbol of Gene | MOG |
| Species | Homo sapiens |
| Entrez Gene ID | 4340 |
| Official Full Name | myelin oligodendrocyte glycoprotein |
| Also known as | BTN6; BTNL11; MOGIG2; NRCLP7 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000204655 MIM:159465; AllianceGenome:HGNC:7197 |
| Map Location | 6p22.1 |
| Variation Type | restriction fragment length polymorphism (RFLP) |
| refSNP ID | 1.9 kb Taq 1 |
Sample information of multiple sclerosis:
| Detected Sample | venous blood |
| Sample Detail | N/A |
| Detected Method | Southern blotting |
| Disease | MS |
| Disease subtype | N/A |
| Population | Southampton area |
| Sample Size | 40 patients with MS / 80 age and sex matched controls |
Literature information of multiple sclerosis :
| Pubmed ID | 9436746 |
| Year | 1998 |
| Title | Lack of association of a Taq 1 polymorphism of the human myelin oligodendrocyte glycoprotein gene with multiple sclerosis in a population of patients from the Southampton area |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | None of these distribution of the Taq1 digest polymorphic bands between patients with multiple sclerosis and controls in the present study differences were statistically significant.The incidence in the two sets of patients with multiple sclerosis is very similar. |
| Mechanism/Pathway | The lesions of multiple sclerosis are most often held to be caused by an immune attack on CNS myelin.The nature of the antigens involved remains obscure, but peptides from at least two major myelin proteins—myelin basic protein and proteolipid protein—are known to cause cell mediated demyelination in animals (experimental allergic encephalomyelitis) which in some ways resembles human multiple sclerosis.Minor myelin components may presumably also act as autoantigens.Myelin oligodendrocyte glycoprotein (MOG) is a quantitatively minor myelin protein localised to oligodendrocyte cell bodies and processes and to the outer layer of CNS myelin sheaths.In common with several other members of this family, MOG has a membrane spanning domain and an extracellular glycosylated N-terminus and its presence on the outermost surface of myelin and the oligodendrocyte plasma membrane may make MOG accessible to the immune system. |
