Basic information of IL7R :
| Official Symbol of Gene | IL7R |
| Species | Homo sapiens |
| Entrez Gene ID | 3575 |
| Official Full Name | interleukin 7 receptor |
| Also known as | ILRA; CD127; IL7RA; CDW127; IMD104; sIL-7R; lnc-IL7R; IL7Ralpha; IL-7Ralpha; IL-7R-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000168685 MIM:146661; AllianceGenome:HGNC:6024 |
| Map Location | 5p13.2 |
| Variation Type | SNP |
| refSNP ID | rs13188960 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method |
the Sequenom MassARRAY |
| Disease | MS |
| Disease subtype | N/A |
| Population | Jordanian Arab |
| Sample Size | 218 MS patients / 227 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 32683075 |
| Year | 2020 |
| Title | Candidate gene association analysis of multiple sclerosis in the Jordanian Arab population: A case-control study |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | This SNP was found to be associated with an increased risk of MS. |
| Mechanism/Pathway | IL7R which was identified as one of the non-major Histocompatibility complex (non - MHC) genes is translated into a functional cell receptor for IL-7. IL7R plays an essential role in the maintenance, survival, homeostasis and proliferation of T cells, and may also have a key signalling influence through autoimmunity process. |
