Basic information of LAG3 :
| Official Symbol of Gene | LAG3 |
| Species | Homo sapiens |
| Entrez Gene ID | 3902 |
| Official Full Name | lymphocyte activating 3 |
| Also known as | CD223 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000089692 MIM:153337; AllianceGenome:HGNC:6476 |
| Map Location | 12p13.31 |
| Variation Type | SNP |
| refSNP ID | rs2365095 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method |
the Sequenom MassARRAY |
| Disease | MS |
| Disease subtype | N/A |
| Population | Jordanian Arab |
| Sample Size | 218 MS patients / 227 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 32683075 |
| Year | 2020 |
| Title | Candidate gene association analysis of multiple sclerosis in the Jordanian Arab population: A case-control study |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | This SNP was found to be associated with an increased risk of MS. |
| Mechanism/Pathway | LAG3 which is another candidate gene involved in the MS susceptibility is encoded to 498-amino acid type I transmembrane protein (LAG3 or CD223) and mainly inhibit the activation of T cells, B cells, and natural killer (NK) cells. |
