Basic information of IGH :

Official Symbol of Gene	IGH
Species	Homo sapiens
Entrez Gene ID	3492
Official Full Name	immunoglobulin heavy locus
Also known as	IGD1; IGH@; IGHJ; IGHV; IGHD@; IGHJ@; IGHV@; IGH.1@; IGHDY1
Gene Type	protein coding
dbXrefs	MIM:146910; MIM:147010; MIM:147070; AllianceGenome:HGNC:5477
Map Location	14q32.33
Variation Type	CNV
refSNP ID	VH4-34 genecopy number

Sample information of multiple sclerosis:

Detected Sample	whole blood
Sample Detail	N/A
Detected Method	Real Time PCR
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	30 MS patients / 30 healthy controls

Literature information of multiple sclerosis :

Pubmed ID	36640058
Year	2022
Title	Biological Features of CD5+ CD19+ B1 Cell and Natural IgM (VH4-34) in Chronic Lymphocytic Leukemia vs. Multiple Sclerosis

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Positive
Result	MS patients had significantly lower VH4-34 gene copy number levels compared to the control group.
Mechanism/Pathway	Natural IgM (nIgM) antibodiesregulate the immune system against autoantigens andare essential for maintaining tissue homeostasis.The anti-inflammatory actions of B1 cells include the generation of nIgM bythe spleen and bone marrow as a primary response to pathogen invasions,the removal of necrotic and apoptotic cells,the maintenance of tissue homeostasis the reductionof inflammatory cytokines, and enhanced release of GcMAF. SeveralVH genes encode natural antibodies, but the VH4-34 gene appears to be the most common.An interesting featureis that the framework region 1 (FWR1) mediates self-antigen binding,and the VH4-34 gene is essentialfor encoding nIgM.