Basic information of LAG3 :
| Official Symbol of Gene | LAG3 |
| Species | Homo sapiens |
| Entrez Gene ID | 3902 |
| Official Full Name | lymphocyte activating 3 |
| Also known as | CD223 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000089692 MIM:153337; AllianceGenome:HGNC:6476 |
| Map Location | 12p13.31 |
| Variation Type | SNP |
| refSNP ID | rs870849 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral leukocytes of venous blood samples |
| Sample Detail | N/A |
| Detected Method | Real Time PCR |
| Disease | MS |
| Disease subtype | RRMS, PPMS, SPMS |
| Population | Caucasian Spanish |
| Sample Size | 300 MS patients / 400 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 36499569 |
| Year | 2022 |
| Title | Association between LAG3/CD4 Genes Variants and Risk for Multiple Sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | The frequencies of the LAG3 rs878049 genotypes and allelic variants that were in the Hardy–Weinberg equilibrium, both in MS patients and in controls, did not differ significantly between the two study groups when comparing the whole series and when analyzed each gender separately. |
| Mechanism/Pathway | LAG3 protein is encoded by the lymphocyte activation gene 3 (LAG3). This protein is expressed by regulatory T cells, both activated and exhausted CD4+ and CD8+ T cells, and microglia, and its main mechanism of action is to deliver inhibitory signals that are involved in the regulation of immune cell homeostasis, T cell activation and proliferation, production of cytokines, cytolytic activity, and other functions related to inflammatory responses. |
