Basic information of CD4 :
| Official Symbol of Gene | CD4 |
| Species | Homo sapiens |
| Entrez Gene ID | 920 |
| Official Full Name | CD4 molecule |
| Also known as | T4; IMD79; Leu-3; OKT4D; CD4mut |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000010610 MIM:186940; AllianceGenome:HGNC:1678 |
| Map Location | 12p13.31 |
| Variation Type | SNP |
| refSNP ID | rs951818 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral leukocytes of venous blood samples |
| Sample Detail | N/A |
| Detected Method | Real Time PCR |
| Disease | MS |
| Disease subtype | RRMS, PPMS, SPMS |
| Population | Caucasian Spanish |
| Sample Size | 300 MS patients / 400 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 36499569 |
| Year | 2022 |
| Title | Association between LAG3/CD4 Genes Variants and Risk for Multiple Sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | The frequencies of the CD4 rs951818 genotypes and allelic variants that were in the Hardy–Weinberg equilibrium, both in MS patients and in controls, did not differ significantly between the two study groups when comparing the whole series and when analyzed each gender separately. |
| Mechanism/Pathway | The CD4 molecule gene which is closely related to the LAG3 gene, encodes the CD4 membrane glycoprotein of T lymphocytes. This glycoprotein is also an important mediator of immune and inflammatory responses. |
