Basic information of IL1A :
| Official Symbol of Gene | IL1A |
| Species | Homo sapiens |
| Entrez Gene ID | 3552 |
| Official Full Name | interleukin 1 alpha |
| Also known as | IL1; IL-1A; IL1F1; IL1-ALPHA; IL-1 alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000115008 MIM:147760; AllianceGenome:HGNC:5991 |
| Map Location | 2q14.1 |
| Variation Type | polymorphism |
| refSNP ID | IL-1 α(-889 T/C) |
Sample information of multiple sclerosis:
| Detected Sample | PBMCs |
| Sample Detail | N/A |
| Detected Method | CTS-PCR-SSP |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Iranian |
| Sample Size | 100 RRMS patients / 140 normal individuals |
Literature information of multiple sclerosis :
| Pubmed ID | 18322311 |
| Year | 2008 |
| Title | IL-1, IL-1R and TNFalpha gene polymorphisms in Iranian patients with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Although there was no significant difference in the single allele distribution between patients and controls,genotype analysis revealed significant differences in TC and TT genotypes between these two groups .The results of our data indicate the decrease in frequency of IL-1alpha TC-889 genotype in the patients group versus normal subjects. On the other hand the frequency of IL-1alpha TT -889 genotype decreased significantly in the patients versus normal subjects. |
| Mechanism/Pathway | It has been demonstrated that polymorphisms of many cytokine genes affect the transcriptional activities,resulting in individual variation in cytokine production.Individual variations in the cytokine production,might affect on many autoimmune diseases such as MS. |
