Basic information of TNF :
| Official Symbol of Gene | TNF |
| Species | Homo sapiens |
| Entrez Gene ID | 7124 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000232810 MIM:191160; AllianceGenome:HGNC:11892 |
| Map Location | 6p21.33 |
| Variation Type | polymorphism |
| refSNP ID | TNFF-α (-308 G/A and -238G/A) |
Sample information of multiple sclerosis:
| Detected Sample | PBMCs |
| Sample Detail | N/A |
| Detected Method | CTS-PCR-SSP |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Iranian |
| Sample Size | 100 RRMS patients / 140 normal individuals |
Literature information of multiple sclerosis :
| Pubmed ID | 18322311 |
| Year | 2008 |
| Title | IL-1, IL-1R and TNFalpha gene polymorphisms in Iranian patients with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | No allele and genotype was significant in -238 position and alleles were significant in -308 position .Also in -308, significant differences were shown in GG and GA genotypes.The results of our data indicate the decrease in frequency of TNF-alpha A-308 allele and AG genotype in the patients group versus normal subjects.On the other hand the frequency of TNFalpha G -308 allele and GG genotype decreased significantly in the patients versus normal subjects. |
| Mechanism/Pathway | It has been demonstrated that polymorphisms of many cytokine genes affect the transcriptional activities,resulting in individual variation in cytokine production.Individual variations in the cytokine production,might affect on many autoimmune diseases such as MS. |
