Basic information of IL1B :
| Official Symbol of Gene | IL1B |
| Species | Homo sapiens |
| Entrez Gene ID | 3553 |
| Official Full Name | interleukin 1 beta |
| Also known as | IL-1; IL1F2; IL1beta; IL1-BETA |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000125538 MIM:147720; AllianceGenome:HGNC:5992 |
| Map Location | 2q14.1 |
| Variation Type | polymorphism |
| refSNP ID | IL-1β (-511 C/T and +3962 C/T) |
Sample information of multiple sclerosis:
| Detected Sample | PBMCs |
| Sample Detail | N/A |
| Detected Method | CTS-PCR-SSP |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Iranian |
| Sample Size | 100 RRMS patients / 140 normal individuals |
Literature information of multiple sclerosis :
| Pubmed ID | 18322311 |
| Year | 2008 |
| Title | IL-1, IL-1R and TNFalpha gene polymorphisms in Iranian patients with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Two positions including -511 in promoter and + 3962 in encoding region, were studied.Analysis on allele and genotype frequency of -511 positions revealed no significant statistical difference in patient and normal group. In +3962 position,CC and CT genotypes revealed significant differences . The results of our data indicate the decrease in frequency of IL-1beta TC +3962 genotype in the patients group versus normal subjects. |
| Mechanism/Pathway | It has been demonstrated that polymorphisms of many cytokine genes affect the transcriptional activities,resulting in individual variation in cytokine production.Individual variations in the cytokine production,might affect on many autoimmune diseases such as MS. |
