Basic information of TNF :
| Official Symbol of Gene | TNF |
| Species | Homo sapiens |
| Entrez Gene ID | 7124 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000232810 MIM:191160; AllianceGenome:HGNC:11892 |
| Map Location | 6p21.33 |
| Variation Type | polymorphism |
| refSNP ID |
TNF-α |
Sample information of multiple sclerosis:
| Detected Sample | EDTA-treated blood |
| Sample Detail | N/A |
| Detected Method | PCR-RFLP |
| Disease | MS |
| Disease subtype | RRMS, PPMS |
| Population | N/A |
| Sample Size | 45 PPMS patients / 45 age and sex-matched RRMS patients / 45 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 19201038 |
| Year | 2009 |
| Title | Tumour necrosis factor alpha gene (TNF-alpha) -376 polymorphism in Hungarian patients with primary progressive multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | We could not detect the AA homozygote genotype in either the MS patients or the HC.For the GG genotype, a statistically significant higher level was found in the PPMS group as compared with the HC group.As regards the G allele, a significant difference was observed between the PPMS and HC groups. The GA genotype was underrepresented in the PPMS group relative to the HC group; for the A allele, the distribution was similar. |
| Mechanism/Pathway | Tumour necrosis factor (TNF) is a proinflammatory cytokine involved in the pathogenesis of infectious and autoimmune disorders, including MS. TNF causes apoptotic cell death, cellular proliferation, differentiation, inflammation and tumourgenesis. |
