Basic information of TNF :
| Official Symbol of Gene | TNF |
| Species | Homo sapiens |
| Entrez Gene ID | 7124 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000232810 MIM:191160; AllianceGenome:HGNC:11892 |
| Map Location | 6p21.33 |
| Variation Type | SNP |
| refSNP ID | rs1800629 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | PCR-RFLP |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Caucasian |
| Sample Size | 183 RRMS patients / 169 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 33252003 |
| Year | 2021 |
| Title | Association of polymorphism -308G/A in tumor necrosis factor-alpha gene ( TNF-α) and TNF-α serum levels in patients with relapsing-remitting multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The differences in genotype distribution were observed after stratification by gender.The female patients showed a significantly elevated frequency of heterozygotes lsthose carrying at least one A-allele (GA/AA genotype) in comparison with the healthy women.In opposite, the distribution of genotypes in men was similar in the group of patients and controls.The frequency of heterozygote GA-genotype was overrepresented among RRMS women with early-onset compared with healthy women.Also, in women with an early manifestation of RRMS, the frequency of A-allele was significantly higher and the wild GG-genotype was less frequent compared with the women of the control group.The distribution of genotype in male patients with early and late-onset of RRMS was lower than healthy men without reaching statistical significance.Moreover, the carriers of at least one A-allele of -308G/A TNF-α polymorphism (GA+AA) are significantly associated with two fold increased risk for RRMS development in women in contrast to men as well as associated with early onset of the disease. |
| Mechanism/Pathway | Tumor necrosis factor-alpha (TNF-α) is a potent pro-inflammatory cytokine with a pleiotropic effect,involved in acute and systemic inflammation.TNF-α interacts with two cell-surface TNF receptors–TNFR1 (55kDa) and TNFR2 (75 kDa) and triggers the cell survival and pro-inflammatory NF-kB and MAP kinases activation. |
