Basic information of TNFSF10 :

Official Symbol of Gene	TNFSF10
Species	Homo sapiens
Entrez Gene ID	8743
Official Full Name	TNF superfamily member 10
Also known as	TL2; APO2L; CD253; TANCR; TRAIL; Apo-2L; TNLG6A
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000121858 MIM:603598; AllianceGenome:HGNC:11925
Map Location	3q26.31
Variation Type	polymorphism
refSNP ID	N/A

Sample information of multiple sclerosis:

Detected Sample	PBMC
Sample Detail	N/A
Detected Method	PCR-SSCP
Disease	MS
Disease subtype	RRMS, PPMS
Population	N/A
Sample Size	123 RRMS patients / 15 PPMS patients / 125 healthy controls

Literature information of multiple sclerosis :

Pubmed ID	15020080
Year	2004
Title	Identification and functional characterization of a highly polymorphic region in the human TRAIL promoter in multiple sclerosis

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Negative
Result	Significant differences were found neither between MS patients and healthy controls nor between different disease courses.
Mechanism/Pathway	Both elimination of T cells and damage to the CNS by immune cells are central pathogenic mechanisms of MS. While elimination of T cells by apoptosis is a physiological control mechanism, tissue damage in the CNS is a pathophysiological feature. During the past few years, several death receptor/ ligand systems mediating apoptosis have been discovered. We could previously show that TRAIL is able to induce massive neuronal cell destruction in the human brain.Since TRAIL receptors, but not the ligand, are expressed in the normal human brain and human antigen-specific T cells upregulate TRAIL upon activation, we expected a role of the TRAIL system in neuroinflammation.